Leukopenia, hypoxia, and complement function with different hemodialysis membranes
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چکیده
منابع مشابه
Leukopenia, hypoxia, and complement function with different hemodialysis membranes.
Complement activation during exposure of plasma to cuprophan has been postulated to cause leukopenia and hypoxia in hemodialysis patients. To determine if hypoxia is related to leukopenia and if complement activation leads to a depletion of functional complement components, we dialyzed four patients three times sequentially against each of four types of membranes: cuprophan, regenerated cellulo...
متن کاملHemodialysis leukopenia and complement function with different dialyzers.
The relationship between leukopenia and the complement system during hemodialysis was re-examined by studying not only the in vivo effects of four different dialyzer membranes (cellulose hydrate, cuprophan, cellulose acetate, and polyacrilonitrile) on leukocyte counts and complement levels, but especially by investigating the effects of these membranes on complement function in vitro. Whereas f...
متن کاملHemodialysis leukopenia. Pulmonary vascular leukostasis resulting from complement activation by dialyzer cellophane membranes.
Acute leukopenia occurs in all patients during the first hour of hemodialysis with cellophanemembrane equipment. This transient cytopenia specifically involves granulocytes and monocytes, cells which share plasma membrane reactivity towards activated complement components. The present studies document that complement is activated during exposure of plasma to dialyzer cellophane, and that upon r...
متن کاملHypoxemia during hemodialysis: effects of different membranes and dialysate compositions.
Hypoxemia during hemodialysis: Effects of different membranes and dialysate compositions. Arterial oxygen tension (Pa02) and white blood cell (WBC) count decrease during hemodialysis (HD) when certain types of membranes are used. Two mechanisms, impaired gas exchange due to intrapulmonary leucostasis and alveolar hypoventilation, have been proposed. To gain more insight into their respective ro...
متن کاملBiocompatibility of hemodialysis membranes.
Exposure of blood to hemodialysis membranes results in numerous interactions between the blood elements and the membrane. Transformation and adsorption of plasma proteins (such as complement) and activation of blood cells (such as neutrophils and monocytes) have been studied most extensively by nephrologists in recent years. There is no consensus on the definition of biocompatibility for dialyz...
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ژورنال
عنوان ژورنال: Kidney International
سال: 1980
ISSN: 0085-2538
DOI: 10.1038/ki.1980.164